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Visualization is important because a protein s function can often be es tablished or at least approximated from its structure. Using visualization tools, the ef cacy of a particular protein can be predicted, potentially obvi ating the need to run lengthy, costly experimental studies in picking target proteins for use as therapeutic drugs. Biotechnology and information technology are in a tight symbiotic re lationship, in that many of the advances in molecular biology have been made possible by the availability of affordable, powerful computers and software. Many companies in the information technology eld have been saved from extinction by sales to biotechnology companies. A major chal lenge for the bioinformatics community is developing hardware and soft ware that has a proven return on investment (ROI), especially since many of the hardware and software applications have hefty price tags.

(C.82)

If you do not use purchase orders, or if a particular bill is not associated with one, you must enter the bill from scratch. No Items will be available for transfer from a PO, so you must enter all Items from the bill. Follow these steps to enter a new bill: 1. Choose Vendors Enter Bills. The Enter Bills window appears (see Figure 17-4). 2. Check the Bill Received checkbox. 3. Choose the vendor from the Vendor drop-down list, or create a new vendor with <Add New> if needed.

Then for our succession of infinitesimal boosts, we can write the following relation between f3n, the resulting speed in units of the speed of light for the nth application of the infinitesimal boost, and f3n-I, for the (n - 1 )th application:

(C.83)

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4. Check the date in the Date eld, and change it if needed to match the date on the bill. 5. Put the bill number in the Ref. No. eld.

This glossary is intended to cover the terms that readers are most likely to encounter in a corporate prospectus. For additional terms, there are several excellent online resources, including: Pharmaceutical Research and Manufacturers of America. Genomics. phrma.org/lexicon Biotechnology Industry Organization. www.bio.org/er/glossary.asp#b DOE Human Genome Program. www.ornl.gov/TechResources/Human_ Genome/glossary/index.html Amino acid Any of a class of 20 organic acids that are combined to form proteins in living organisms. Applied research Scienti c exploration that is aimed at acquiring speci c knowledge that has commercial objectives. Bacteriophage A virus that infects bacteria but not humans. Base One of the molecules that form DNA and RNA molecules. Base pair Two nitrogenous bases (adenine-thymine or guanine-cytosine) held together by weak bonds. Two strands of DNA are held together in the shape of a double helix by the bonds between base pairs. Basic research Scienti c exploration that advances scienti c knowledge but that does not have any immediate commercial objective. Bioinformatics The study of how information is represented and trans mitted in biological systems, using computer technology. Biological Material License Agreement (BMLA) A worldwide, nonexclu sive license to make, use, and sell unpatented government materials and products. Biologicals Products obtained from living materials as well as bacterial and viral vaccines, antigens, antitoxins, and toxoids. Biotechnology A set of biological techniques developed through basic re search and now applied to product research and development. Carrier An individual who possesses an unexpressed, recessive genetic trait. Although not visible in the carrier, the trait may be inherited by his or her offspring. Chromosome The self-replicating genetic structure of cells containing the cellular DNA that bears in its nucleotide sequence the linear ar ray of genes.

"" 1- f3;-1

(C.84)

You do not have to enter anything in the Amount Due eld because QuickBooks will calculate it based on the Items and expenses you assign to the bill.

n=l 1- f3n- 1

(C.85)

Clinical Trial Agreement (CTA) A document that governs the conduct of clinical studies of the safety and ef cacy of outside collaborators pro prietary biologics or pharmaceutical compounds Clone An exact copy made of biological material It may be a cell or a complete organism Commercial Evaluation License (CEL) Agreement A license that allow a company to evaluate, usually on a short-term basis, the commercial potential of unpatented, patented, and patent-pending materials or methods Comparative genomics The study of human genetics by comparison with model organisms such as mice, the fruit y, and the bacterium E coli Con dential Disclosure Agreement (CDA) An agreement that ensures that government employees do not disclose publicly a company s pro prietary information or trade secrets and that a company does not dis close publicly the government s scienti c ndings before publication and before the government is able to secure patent rights.

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